Calculation

Question -1)

NORAD 8mg in 100 ml is running at 10 ml per hour on an 80 kg patient. What is the mcg per kg per minute of NORAD running at?

  1. Convert dose to micrograms:
    • We have 8 mg of Norad in 100 ml.
    • 8 mg × 1000 = 8000 mcg (Total dose)
  2. Determine the concentration of Norad in the solution:
    • 8000 mcg ÷ 100 ml = 80 mcg/ml
  3. Calculate the infusion rate in mcg per hour:
    • The infusion rate is 10 ml per hour.
    • 10 ml/hr × 80 mcg/ml = 800 mcg/hr
  4. Convert the infusion rate to mcg per minute:
    • 800 mcg/hr ÷ 60 = 13.33 mcg/min
  5. Calculate the dose per kg per minute:
    • Patient’s weight is 80 kg.
    • 13.33 mcg/min ÷ 80 kg = 0.167 mcg/kg/min

Thus, the infusion delivers 0.167 mcg per kg per minute.

Question -2)

5 mg remifentanil diluted in 50 ml running at 7.5mcg/kg/hr on a 75 kg patient. calculate the ml/per hour running at

  1. Convert the remifentanil dose to micrograms:
  1. The solution contains 5 mg of remifentanil.
  2. 5 mg × 1000=5000 mcg
  3. Determine the patient’s required dose in mcg per hour:
    • The rate is 7.5 mcg/kg/hr.
    • For a 75 kg patient: 7.5 mcg/kg/hr × 75 kg = 562.5 mcg/hr
  4. Calculate the concentration of the diluted solution in mcg/ml:
    • The solution contains 5000 mcg in 50 ml.
    • 50ml ÷ 5000mcg ​= 100mcg/ml
  5. Calculate the infusion rate in ml per hour:
  1. To deliver 562.5 mcg per hour:
  2. 562.5 mcg/hr ÷ 100 mcg/ml=5.625 ml/hr

Thus, the infusion rate should be set to 5.625 ml per hour.

Question -3)

1000mcg of dexmedetomidine diluted in 250 ml dextrose running at .5mcg/kg/hr on a 60 kg patient. what is ml/hr

  1. Calculate the patient’s required dose in mcg per hour:
    • Infusion rate = 0.5 mcg/kg/hr
    • Patient weight = 60 kg
    • Required dose per hour:  0.5 mcg/kg/hr × 60 kg = 30 mcg/hr
  2. Determine the concentration of the solution in mcg/ml:
    • The solution has 1000 mcg of dexmedetomidine in 250 ml.
    • Concentration: 1000 mcg ÷ 250 ml=4 mcg/ml
  3. Calculate the infusion rate in ml per hour:
    • To deliver 30 mcg per hour:
    • 30 mcg/hr ÷ 4 mcg/ml = 7.5 ml/hr ​

So, the infusion should run at 7.5 ml per hour.

Question-4) To start Milirinone at 0.475mcg/kg/min to a patient of 75kg . The solution is 10 mg in 50 ml of 5% dextrose. what rate would you start?

Step 1: Convert the milrinone dose to micrograms

  • The solution has 10 mg of milrinone.
  • Since 1 mg=1000 mcg
  • 10 mg×1000=10000 mcg

Step 2: Calculate the required dose for the patient in mcg per minute

  • The infusion rate is 0.475 mcg/kg/min.
  • For a 75 kg patient: 0.475 mcg/kg/min × 75 kg=35.625 mcg

Step 3: Determine the concentration of milirinone in the solution (mcg/ml)

  • The solution has 10000 mcg in 50 ml:
  • 10000 mcg ÷ 50 ml=200 mcg/ml

Step 4: Calculate the infusion rate in ml per minute

  • To deliver 35.625 mcg per minute:
  • ml/min =35.625 mcg/min ÷ 200 mcg/ml = 0.178125 ml/min

Step 5: Convert ml/min to ml/hr

To convert ml/min to ml/hr, multiply by 60:

ml/hr = 0.178125 ml/min× 60 ≈ 10.6875 ml

Final Result

Thus, the infusion rate should be set to approximately 10.69 ml/hr.v

Question -5)

Dobutamine 400mg in 250 ml to a patient of 82 kg. have to start at 5mcg/kg/min, how to calculate

Step 1: Determine the Total Dosage Required in mcg/min

  • The dosage is set at 5 mcg/kg/min.
  • For an 82 kg patient: 5 mcg/kg/min × 82 kg=410 mcg/min

Step 2: Calculate the Concentration of Dobutamine in mcg/ml

  • We have 400 mg of dobutamine in 250 ml of solution.
  • Convert 400 mg to mcg (since 1 mg=1000 mcg )
  • : 400000 mcg 250 ml=1600 mcg/ml ​=1600mcg/ml

Step 3: Calculate the Infusion Rate in ml/hr

  • To deliver 410 mcg/min, we divide by the concentration: ml/min=410 mcg/min1600 mcg/ml=0.25625 ml/min
  • Now, convert this to ml/hr by multiplying by 60: ml/hr=0.25625 ml/min×60=15.375 ml/hr

Final Answer

The infusion rate should be set to approximately 15.38 ml/hr to deliver 5 mcg/kg/min of dobutamine to an 82 kg patient.